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Nootropic Supplements to Boost Brain Function

Nootropics is a class of supplements that have a beneficial effect on the function if your brain and memory. Many of these nootropic supplements can be a great way to gain a boost in everything from memory, motivation, alertness, and overall cognitive function. Here is a list of nootropic supplements out there that you can try to start improving your brain function.

CAFFEINE

One of the most recognized and widely used nootropics, caffeine is a common natural stimulant that works by prompting the brain and central nervous system. While most of us have seen the powerful energizing effects of caffeine, studies have also shown that is effective in improving your memory, increasing reaction times, and increasing your overall brain function.

GINKGO BILOBA

One of the oldest tree species on the planet, ginkgo biloba has been used as a powerful brain booster for centuries. Utilizing the fruits, seeds, and leaves from this tree, ginkgo biloba can alleviate depression and a variety of mental-health conditions, while providing a powerful boost of antioxidants that can improve cognitive function.

CURCUMIN

Found in turmeric, curcumin has been shown to increase mental focus while reducing brain fog. The curcuminoids found in curcumin are effective at fighting oxidative stress caused by free radicals, boosting neural connections in the process.

DHA

This important omega-3 fatty acid plays an important role in boosting brain function and stimulating new growth of brain cells. Research into DHA has even shown it to be an effective chemical in reducing the effects of Alzheimer’s patients.

ACETYL-L-CARNITINE

This amino acid has a number of health benefit that can help reduce the effects of neuroinflammation. It has shown to be effective in reducing the progression of mental deterioration, but it also can be a powerful mood and cognition enhancer, all the while improving focus.

CREATINE

This natural substance is found naturally in the body, If taken in high enough doses, it can improve memory and thinking skills. One study found that taking creatine resulted in an a 25-50% increase in memory when taking an intelligence test, proving it to be a powerful brain boosting nootropic.

RHODIOLA ROSEA

This supplement has been a staple in traditional Chinese medicine and is used to promote overall well-being and healthy brain function. It can also improve mental processing and can be an effective fatigue reducer.

How do Brain Pills work?

What if you could simply take a pill that would instantly make you more intelligent? One that would enhance your cognitive capabilities including attention, memory, focus, motivation and other higher executive functions? If you have ever seen the movie Limitless, you have an idea of what this would look like—albeit the exaggerated Hollywood version. The movie may be fictional but the reality may not be too far behind.

So what Are Brain Pills & Nootropics?

The concept of neuroenhancement and the use of substances to improve cognitive functioning in healthy individuals, is certainly not a new one. In fact, one of the first cognitive enhancement drugs, Piracetam, was developed over fifty years ago by psychologist and chemist C.C. Giurgea. Although he did not know the exact mechanism, Giurgia believed the drug boosted brain power and so began his exploration into “smart pills“, or nootropics, a term he coined from the Greek nous, meaning “mind,” and trepein, meaning “to bend.

Listed below is a brief overview of some of the more frequently used nootropics including wakefulness-promoting agents such as modafinil, and several in the racetam class of drugs, grouped together because of their shared chemical structure. Note that these are not comprehensive descriptions. Those can be found in sources cited.

Piracetam:

The so-called “original smart pill,” Piracetam has been shown in studies to significantly improve cognitive and working memory at all levels. Developed in 1964, it is one of the more researched nootropics in the racetam class of supplements. Piracetam is not approved for use as a medical drug or dietary supplement in the U.S.

Aniracetam:

A synthetic derivative of Piracetam, aniracetam is believed to be the second most widely used nootropic in the Racetam family, popular for its stimulatory effects because it enters the bloodstream quickly. Initially developed for memory and learning, many anecdotal reports also claim that it increases creativity. However, clinical studies show no effect on the cognitive functioning of healthy adult mice.

Oxiracetam:

Popular among computer programmers, oxiracetam, another racetam, has been shown to be effective in recovery from neurological trauma and improvement to long-term memory. It is believed to effective in improving attention span, memory, learning capacity, focus, sensory perception, and logical thinking. It also acts as a stimulant, increasing mental energy, alertness, and motivation.

Modafinil:

Modafinil, sold under the name Provigil, is a stimulant that some have dubbed the “genius pill.” It is a wakefulness-promoting agent (modafinil) and glutamate activators (ampakine). Originally developed as a treatment for narcolepsy and other sleep disorders, physicians are now prescribing it “off-label” to cellists, judges, airline pilots, and scientists to enhance attention, memory and learning. According to Scientific American, “scientific efforts over the past century [to boost intelligence] have revealed a few promising chemicals, but only modafinil has passed rigorous tests of cognitive enhancement.” A stimulant, it is a controlled substance with limited availability in the U.S.

Ginsenoside Rg1:

Ginsenoside Rg1, a molecule found in the plant genus panax (ginseng), is being increasingly researched as an effect nootropic. Its cognitive benefits including increasing learning ability and memory acquisition, and accelerating neural development. It targets mainly the NMDA receptors and nitric oxide synthase, which both play important roles in personal and emotional intelligence. The authors of the study cited above, say that their research findings thus far have boosted their confidence in a “bright future of cognitive drug development.”

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Top Natural Supplements for Brain Health!

Nootropics are natural supplements or drugs that have a beneficial effect on brain function in healthy people. Many of these can boost memory, motivation, creativity, alertness and general cognitive function. Nootropics may also reduce age-related declines in brain function. Here are the 10 best nootropic supplements to boost your brain function!

1. Fish Oils

Fish oil supplements are a rich source of docosahexaenoic acid (DHA) and eicosatetraenoic acid (EPA), two types of omega-3 fatty acids. These fatty acids have been linked with many health benefits, including improved brain health. DHA plays a vital role in maintaining the structure and function of your brain. In fact, it accounts for around 25% of the total fat, and 90% of the omega-3 fat, found in your brain cells. The other omega-3 fatty acid in fish oil, EPA, has anti-inflammatory effects that may protect the brain against damage and aging.

Taking DHA supplements has been linked with improved thinking skills, memory and reaction times in healthy people who have low DHA intakes. It has also benefitted people experiencing a mild decline in brain function. Unlike DHA, EPA isn’t always linked with improved brain function. However, in people with depression, it has been associated with benefits like improved mood. Taking fish oil, which contains both these fats, has been shown to help reduce the decline in brain function associated with aging. However, evidence for fish oil’s preservative effects on brain health is mixed. The overall, the best way to get the recommended amount of omega-3 fatty acids is by eating two portions of oily fish per week. If you can’t manage this, then taking a supplement could be beneficial.

2. Resveratrol

Resveratrol is an antioxidant that occurs naturally in the skin of purple and red fruits like grapes, raspberries and blueberries. It’s also found in red wine, chocolate and peanuts. It’s been suggested that taking resveratrol supplements could prevent the deterioration of the hippocampus, an important part of the brain associated with memory. If this is true, this treatment could slow down the decline in brain function you experience as you get older. Animal studies have also shown that resveratrol can improve memory and brain function. Additionally, one study on a small group of healthy older adults found that taking 200 mg of resveratrol per day for 26 weeksimproved memory.

3. Caffeine

Caffeine is a natural stimulant most commonly found in tea, coffee and dark chocolate. Although it’s possible to take it as a supplement, there isn’t really any need when you can get it from these sources. It works by stimulating the brain and central nervous system, making you feel less tired and more alert. In fact, studies have shown that caffeine can make you feel more energized andimprove your memory, reaction times and general brain function. The amount of caffeine in one cup of coffee varies, but generally it’s 50–400 mg. For most people, single doses of around 200–400 mg per day are generally considered safe and are enough to benefit health.

4. Phosphatidylserine

Phosphatidylserine is a type of fat compound called a phospholipid, which can be found in your brain. It’s been suggested that taking phosphatidylserine supplements could be helpful for preserving brain health. Studies have shown that taking 100 mg of phosphatidylserine three times per day could help reduce age-related decline in brain function. Additionally, healthy people who take phosphatidylserine supplements of up to 400 mg per day have been shown to have improved thinking skills and memory.

5. Acetyl-L-Carnitine

Acetyl-L-carnitine is an amino acid produced naturally in your body. It plays an important role in your metabolism, particularly in energy production. Taking acetyl-L-carnitine supplements has been claimed to make you feel more alert, improve memory and slow down age-related memory loss. Some animal studies have shown that acetyl-L-carnitine supplements can prevent age-related decline in brain function and increase learning capacity. In humans, studies have found that it may be a useful supplement for slowing the decline in brain function due to age. It may also be useful for improving brain function in people with mild dementia or Alzheimer’s.

6. Ginkgo Biloba

Ginkgo biloba is an herbal supplement derived from the Ginkgo biloba tree. It’s an incredibly popular supplement that many people take to boost their brain power. It’s thought to work by increasing blood flow to the brain and is claimed to improve brain functions like focus and memory. Despite the widespread use of ginkgo biloba, results from studies investigating its effects have been mixed. Some studies have found that taking ginkgo biloba supplements can help reduce age-related decline in brain function. One study in healthy middle-aged people found that taking ginkgo biloba supplements helped improve memory and thinking skills.

7. Creatine

Creatine is a natural substance that plays an important role in energy metabolism. It’s found naturally in the body, mostly in muscles and in smaller amounts in the brain. Although it’s a popular supplement, you can find it in some foods, namely animal products like meat, fish and eggs. Interestingly, creatine supplements can improve memory and thinking skills in people who don’t eat meat. In fact, one study found that vegetarians taking creatine supplements experienced a 25–50% improvement in performance on a memory and intelligence test. However, meat eaters don’t see the same benefits. This may be due to the fact that they are not deficient and already get enough from their diets. BOTTOM LINE: Taking creatine supplements could help improve memory and thinking skills in people who don’t eat meat.

8. Bacopa Monnieri

Bacopa monnieri is a medicine made from the herb Bacopa monnieri. It’s used in traditional medicine practices like Ayurveda for improving brain function. It’s been shown to improve thinking skills and memory, both in healthy people and in elderly people suffering from a decline in brain function. However, it’s worth noting that only repeated use of Bacopa monnieri has been shown to have this effect. People generally take about 300 mg per day and it may take around four to six weeks for you to notice any results. Studies of Bacopa monnieri also show that it may occasionally cause diarrhea and an upset stomach. Because of this, many people recommend taking this supplement with food. BOTTOM LINE: Bacopa monnieri has been shown to improve memory and thinking skills in healthy people and in those with a decline in brain function.

9. Rhodiola Rosea

Rhodiola rosea is a supplement derived from the herb Rhodiola rosea, which is often used in Chinese medicine to promote well-being and healthy brain function. It’s thought to help improve mental processing by reducing fatigue. People taking Rhodiola rosea have been shown to benefit from a decrease in fatigue and improvement in their brain function. However, results have been mixed.

10. S-Adenosyl Methionine

S-Adenosyl methionine (SAMe) is a substance that occurs naturally in your body. It’s used in chemical reactions to make and break down important compounds like proteins, fats and hormones. It may be useful for enhancing the effects of some antidepressants and reducing the decline in brain function seen in people who have depression. One study found that adding SAMe to the antidepressant prescription of people who had previously not responded to therapy improved their chances of remission by around 14%. More recently, a study found that, in some instances, SAMe may be as effective as some types of antidepressant medications.

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WHAT IS ORGANIC LION’S MANE MUSHROOM?

Lion’s mane mushrooms are large, white, shaggy mushrooms that resemble a lion’s mane as they grow. They have both culinary and medical uses in Asian countries like China, India, Japan and Korea.  Lion’s mane mushrooms can be enjoyed raw, cooked, dried or steeped as a tea, their extracts often used in over-the-counter health supplements. Many describe their flavor as “seafood-like,” often comparing it to crab or lobster.  Lion’s mane mushrooms contain bioactive substances that have beneficial effects on the body, especially the brain, heart and gut.

Here are 6 health benefits of lion’s manemushrooms and their extracts!

1. Could Protect Against Dementia:

The brain’s ability to grow and form new connections typically declines with age, which may explain why mental functioning gets worse in many older adults. Studies have found that lion’s mane mushrooms contain two special compounds that can stimulate the growth of brain cells: hericenones and erinacines.

Additionally, animal studies have found that lion’s mane may help protect against Alzheimer’s disease, a degenerative brain disease that causes progressive memory loss. In fact, lion’s mane mushroom and its extracts have been shown to reduce symptoms of memory loss in mice, as well as prevent neuronal damage caused by amyloid-beta plaques, which accumulate in the brain during Alzheimer’s disease. 

While no studies have analyzed whether lion’s mane mushroom is beneficial for Alzheimer’s disease in humans, it appears to boost mental functioning. A study in older adults with mild cognitive impairment found that consuming 3 grams of powdered lion’s mane mushroom daily for four months significantly improved mental functioning, but these benefits disappeared when supplementation stopped. 

The ability of lion’s mane mushroom to promote nerve growth and protect the brain from Alzheimer’s-related damage may explain some of its beneficial effects on brain health. However, it’s important to note that most of the research has been conducted in animals or in test tubes.

SUMMARY:

Lion’s mane mushrooms contain compounds that stimulate the growth of brain cells and protect them from damage caused by Alzheimer’s disease. However, more human research is needed.

2. Helps Relieve Mild Symptoms of Depression and Anxiety:

Up to one-third of people living in developed countries experience symptoms of anxiety and depression. While there are many causes of anxiety and depression, chronic inflammation could be a major contributing factor. New animal research has found that lion’s mane mushroomextract has anti-inflammatory effects that can reduce symptoms of anxiety and depression in mice.

Other animal studies have found that lion’s mane extract can also help regenerate brain cells and improve the functioning of the hippocampus, a region of the brain responsible for processing memories and emotional responses. Researchers believe that improved functioning of the hippocampus may explain the reductions in anxious and depressive behaviors in mice given these extracts.

While these animal studies are promising, there is very little research in humans. One small study in menopausal women found that eating cookies containing lion’s mane mushrooms daily for one month helped reduce self-reported feelings of irritation and anxiety. 

SUMMARY:

Studies suggest that lion’s mane mushrooms may help relieve mild symptoms of anxiety and depression, but more human research is needed to better understand the correlation.

3. May Speed Recovery from Nervous System Injuries:

The nervous system consists of the brain, spinal cord and other nerves that travel throughout the body. These components work together to send and transmit signals that control almost every bodily function. Injuries to the brain or spinal cord can be devastating. They often cause paralysis or loss of mental functions and can take a long time to heal.

However, research has found that lion’s mane mushroom extract may help speed recovery from these types of injuries by stimulating the growth and repair of nerve cells. In fact, lion’s manemushroom extract has been shown to reduce recovery time by 23–41% when given to rats with nervous system injuries. Lion’s mane extract may also help reduce the severity of brain damage after a stroke.

In one study, high doses of lion’s mane mushroom extract given to rats immediately after a stroke helped decrease inflammation and reduce the size of stroke-related brain injury by 44%, while these results are promising, no studies have been conducted in humans to determine if lion’s mane would have the same therapeutic effect on nervous system injuries.

SUMMARY:

Rat studies have found that lion’s mane extract can speed up recovery time from nervous system injuries, but human research is lacking.

4. Protects Against Ulcers in the Digestive Tract:

Ulcers are capable of forming anywhere along the digestive tract, including the stomach, small intestine and large intestine.
Stomach ulcers are often caused by two major factors: overgrowth of a bacteria called H. pyloriand damage to the mucous layer of the stomach that’s often due to long-term use of non-steroidal anti-inflammatory drugs. Lion’s mane extract may protect against the development of stomach ulcers by inhibiting the growth of H. pylori and protecting the stomach lining from damage.

Several studies have found that lion’s mane extract can prevent the growth of H. pylori in a testtube, but no studies have tested whether they have the same effects inside the stomach. Additionally, an animal study found that lion’s mane extract was more effective at preventing alcohol-induced stomach ulcers than traditional acid-lowering drugs — and without any negative side effects.

Lion’s mane extract can also reduce inflammation and prevent tissue damage in other areas of the intestines. In fact, they may help treat inflammatory bowel diseases like ulcerative colitis and Crohn’s disease. One study in people with ulcerative colitis found that taking a mushroom supplement containing 14% lion’s mane extract significantly reduced symptoms and improved quality of life after three weeks.

However, when the same study was repeated in patients with Crohn’s disease, the benefits were no better than a placebo. It’s important to note that the herbal supplement used in these studies included several types of mushrooms, so it’s difficult to draw any conclusions about the effects of lion’s mane specifically. Overall, research suggests that lion’s mane extract may help inhibit the development of ulcers. 

SUMMARY:

Lion’s mane extract has been shown to protect against stomach and intestinal ulcers in rodents, but human research has been conflicting.

5. Reduces Heart Disease Risk:

Major risk factors for heart disease include obesity, high triglycerides, large amounts of oxidized cholesterol and an increased tendency to get blood clots.
Research shows that lion’s mane extract can influence some of these factors and reduce the risk of heart disease. Studies in rats and mice have found that lion’s mane mushroom extract improves fat metabolism and lowers triglyceride levels. 

One study in rats fed a high-fat diet and given daily doses of lion’s mane extract observed 27% lower triglyceride levels and 42% less weight gain after 28 days! Since obesity and high triglycerides are both considered risk factors for heart disease, this is one way that lion’s mane mushrooms contribute to heart health.

Test-tube studies have also found that lion’s mane extract can help prevent the oxidation of cholesterol in the bloodstream. Oxidized cholesterol molecules tend to attach to the walls of arteries, causing them to harden and increasing the risk of heart attack and stroke. Therefore, reducing oxidation is beneficial for heart health.

What’s more, lion’s mane mushrooms contain a compound called hericenone B, which can decrease the rate of blood clotting and lower the risk of heart attack or stroke. Lion’s mane mushrooms appear to benefit the heart and blood vessels in multiple ways, but human studies are needed to support this.

SUMMARY:

Animal and test-tube studies suggest that lion’s mane extract can reduce the risk of heart disease in several ways, but human studies are needed to confirm these findings.

6. May Help Fight Cancer:

Cancer occurs when DNA becomes damaged and causes cells to divide and replicate out of control. Some research suggests that lion’s mane mushroom has cancer-fighting abilities, thanks to several of its unique compounds.

In fact, when lion’s mane extract is mixed with human cancer cells in a test tube, they cause the cancer cells to die at a faster rate. This has been demonstrated with several types of cancer cells, including liver, colon, stomach and blood cancer cells. However, at least one study has failed to replicate these results, so more studies are needed.

In addition to killing cancer cells, lion’s mane extract has also been shown to slow the spread of cancer. One study in mice with colon cancer found that taking lion’s mane extract reduced the spread of cancer to the lungs by 69%!

Another study found that lion’s mane extract was more effective than traditional cancer medications at slowing tumor growth in mice, in addition to having fewer side effects. However, the anti-cancer effects of lion’s mane mushroom have never been tested in humans, so more research is needed.

SUMMARY:

Animal and test-tube studies show that lion’s mane extract can kill cancer cells and slow the spread of tumors, but human studies are still needed.